When it comes to immunity, women has the advantage

Researchers at McGill University have recently shown that estrogen imparts an extra measure of protection for the fairer sex. In a study on knock-out mice lacking the gene for Caspase-12, an enzyme which blocks the innate immune system's ability to induce inflammation, it was shown that when the human Caspase-12 gene was implanted into a group of these infection-resistant mice, that only males became more susceptible to infection. Researchers were also able to specifically locate the inhibitory binding site of estrogen on Caspase-12, indicating a direct mechanism for the blocking of Caspase-12 by estrogen. This study has implications on future, estrogen-based immune enhancing treatment.

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Khang